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KMID : 0390220180290010087
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Journal of Clinical Otolaryngology, Head and Neck Surgery
2018 Volume.29 No. 1 p.87 ~ p.90
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Sudden Sensorineural Hearing Loss after Granulocyte-Colony Stimulating Factor Administration
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Kim Seon-Lin
Oh Se-Joon
Kong Soo-Keun
Goh Eui-Kyung
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Abstract
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Filgrastimⓡ (Granulocyte-colony stimulating factor, G-CSF) is generally used to promote the increase of neutrophils to patients with neutropenia during chemotherapy or donors for hematopoietic stem cell transplantation (HSCT). Its adverse effects were mainly reported as non-serious symptoms, such as back pain, headache, arthralgia and fever. A 29-year-old male was administered the Filgrastim as a HSCT donor. He accompanied left side hearing disturbance and tinnitus after 2 days from administration of the drug. He admitted to our department and underwent improvement of hearing after high dose steroid therapy. In this report, we describe a case of sudden sensorineural hearing loss (SSNHL) as an unreported adverse effect of G-CSF in the literature.
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KEYWORD
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Filgrastim, Neutrophil-to-lymphocyte ratio, Sudden sensorineural hearing loss, Granulocyte-colony stimulating factor
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